Abstract: Based on the target delineated by geochemical anomaly, combining geophysical method, the Jiyuan lead-zinc deposit, which is similar to the Mississippi Valley Type(MVT), is found in the Upper Cambrian dolomite in Northwestern Henan Province. The orebodies, occurring in thick-bedded dolomite, are closely related to the horizons and structures. The intersections of structures with different times and various levels obviously control the formation of the lead-zinc deposit. With the analysis on the characteristics and prospecting signs of the deposit, the new exploration methods on such type of lead-zinc deposits are concluded, which provide some experiences for further prospecting.