Abstract: The study adopts the minerogenetic series theory of mineral deposits to divide the minerogenetic series, construct the minerogenetic evolution path, and summarize the metallogenic environment and spatiotemporal evolution regularity of mineralization in southern Jilin Province in different tectonic evolution periods. The result establishes 4 deposit minerogenetic series groups, 3 minerogenetic series combinations, 3 minerogenetic series types, 12 minerogenetic series, 16 minerogenetic subseries and 27 deposit types in different geological periods from Neoarchean to Cenozoic. Taking the tectonic evolution stage as abscissa axis and the evolution cycle as ordinate axis, the evolution path diagram of mineralization is completed, with each minerogenetic series group (combination, type), minerogenetic series, minerogenetic subseries and deposit type at a specific position. The diagram reflects the interrelation between the cyclicity of tectonic evolution and regularity of mineralization, the attribute connotation of each sequence of metallogenic series and their mutual relations, as well as the history of tectonic evolution and metallogenic process in southern Jilin Province, which is an objective record of mineralization in different tectonic evolution cycles in the area.