Abstract: The super large Zhugongtang Pb-Zn deposit is recently identified in northwestern Guizhou Province. The content and occurrence of dispersed elements in the ore minerals of the deposit are analyzed by electron probe microanalyzer(EPMA) and inductively coupled plasma mass spectrometry(ICP-MS). The results show that the ores contain multiple dispersed elements including Ge, Tl, Ga, Cd, In and Se, which may occur in sulfide minerals in the form of isomorphism. Specifically, the elements of Cd, Ga, Se and In are mainly enriched in sphalerite, while Tl and Ge mainly in galena. By analyzing the Cd content, Zn/Cd and Ga/In values in sphalerite, it is preliminarily considered that Zhugongtang Pb-Zn deposit may be of hydrothermal sedimentary transformation type genetically.