Abstract: The Puzhengou lead-zinc-silver polymetallic deposit, a newly discovered deposit within the Puzhengou pluton in western Henan Province, is a significant component of the Lushi polymetallic ore-concentrated area in the eastern Qinling metallogenic belt. The orebodies are hosted in the strata of Guandaokou Group, strictly controlled by the interlayer fracture zone between the quartz sandstone of Gaoshanhe Formation and dolomite of Longjiayuan Formation. Two Pb-Zn-Ag polymetallic orebodies have been delineated, with the metal reserves of indium, the associated scarce element, reaching large scale, while the resources of lead-zinc are expected to attain a medium scale. Based on the geological, geophysical and geochemical characteristics, combined with the mineral paragenesis, isotopic composition, and age data, it is preliminarily considered that the Puzhengou Pb-Zn-Ag polymetallic deposit was formed during Late Jurassic-Early Cretaceous, with the ore-forming materials of mantle-crust mixing source. The deposit is genetically related to Yanshanian granite porphyry, belonging to post-magmatic hydrothermal vein type.